Mechanisms for lung function impairment and airway hyperresponsiveness following chronic hypoxia in rats
نویسندگان
چکیده
منابع مشابه
Mechanisms for lung function impairment and airway hyperresponsiveness following chronic hypoxia in rats.
Although chronic normobaric hypoxia (CH) alters lung function, its potential to induce bronchial hyperreactivity (BHR) is still controversial. Thus the effects of CH on airway and tissue mechanics separately and changes in lung responsiveness to methacholine (MCh) were investigated. To clarify the mechanisms, mechanical changes were related to end-expiratory lung volume (EELV), in vivo results ...
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متن کاملStriatal dopamine levels and changes in mitochondrial function following chronic 3-nitropropionic acid treatment in rats
An irreversible inhibitor of complex II in the mitochondria, 3-nitropropionic acid (3-NP), induces bilateral striatal lesions with many neuropathological features of Huntington’s disease (HD) in rats. It is widely used as a model of HD. Chronic systemic treatment of 3-NP for 4 days in rats (10, 15 and 20 mg/kg) caused a significant dose-dependent reduction in succinate dehydrogenase activity, w...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Lung Cellular and Molecular Physiology
سال: 2010
ISSN: 1040-0605,1522-1504
DOI: 10.1152/ajplung.00222.2009